PMID: 39433176

Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners. Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Sellick K, Spears E, Poffenberger G, Schornack AMR, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Mol Metab. 2024 Oct 20;90:102050. doi: 10.1016/j.molmet.2024.102050

 

PMID: 39433757

Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice. Dos Santos C, Cambraia A, Shrestha S, Cutler M, Cottam M, Perkins G, Lev-Ram V, Roy B, Acree C, Kim KY, Deerinck T, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, Arrojo E Drigo R. Nat Commun. 2024 Oct 21;15(1):9063. doi: 10.1038/s41467-024-53127-2.

 

PMID: 38658223

The consumption of animal products is associated with plasma levels of alpha-aminoadipic acid (2-AAA). Antonetti OR, Desine S, Smith HM, Robles ME, McDonald E, Ovide G, Wang C, Dean ED, Doran AC, Calcutt MW, Huang S, Brown JD, Silver HJ, Ferguson JF. Nutr Metab Cardiovasc Dis. 2024 Jul;34(7):1712-1720. doi: 10.1016/j.numecd.2024.03.009.

​

PMID: 38944125

ErbB3 is required for hyperaminoacidemia-induced pancreatic α cell hyperplasia. Kang Q, Jia J, Dean ED, Yuan H, Dai C, Li Z, Jiang F, Zhang XK, Powers AC, Chen W, Li M. J Biol Chem. 2024 Jun 27;300(8):107499. doi: 10.1016/j.jbc.2024.107499. 

​​

PMID: 37645716

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2. Spears E.; Stanley JE; Shou M; Yin L; Li X; Dai C; Bradley A; Sellick K; Poffenberger G; Coate KC; Shrestha S; Jenkins R; Sloop KW; Wilson KT; Attie AD; Keller MP; Chen W; Powers AC; Dean ED. bioRxiv: 2023.2008.2010.552656.
 

PMID: 37367959.

100 years of glucagon and 100 more. Wewer Albrechtsen NJ, Holst JJ, Cherrington AD, Finan B, Gluud LL, Dean ED, Campbell JE, Bloom SR, Tan TM, Knop FK, Müller TD. Diabetologia. 2023 Aug;66(8):1378-1394. doi: 10.1007/s00125-023-05947-y. 

 

PMID: 37607124

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue. Crabtree A, Neikirk K, Marshall AG, Vang L, Whiteside AJ, Williams Q, Altamura CT, Owens TC, Stephens D, Shao B, Koh A, Killion M, Lopez EG, Lam J, Rodriguez B, Mungai M, Stanley J, Dean ED, Koh HJ, Gaddy JA, Scudese E, Sweetwyne MT, Davis J, Zaganjor E, Murray SA, Katti P, Damo SM, Vue Z, Hinton A Jr. Adv Biol (Weinh). 2023 Aug 21:e2300186. doi: 10.1002/adbi.202300186. 

 

PMID: 37523232

Metabolic regulation of glucagon secretion. Armour SL, Stanley JE, Cantley J, Dean ED, Knudsen JG. J Endocrinol. 2023 Jul 1:JOE-23-0081. doi: 10.1530/JOE-23-0081.

 

PMID: 36646689

Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways. Gong Y, Yang B, Zhang D, Zhang Y, Tang Z, Yang L, Coate KC, Yin L, Covington BA, Patel RS, Siv WA, Sellick K, Shou M, Chang W, Dean ED, Powers AC, Chen W. Nat Commun. 2023 Jan 16;14(1):235. doi: 10.1038/s41467-022-35705-4. 

​

PMID: 33619103

Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.

Wang MY, Dean ED, Quittner-Strom E, Zhu Y, Chowdhury KH, Zhang Z, Zhao S, Li N, Ye R, Lee Y, Zhang Y, Chen S, Yu X, Leonard DC, Poffenberger G, Von Deylen A, McCorkle SK, Schlegel A, Sloop KW, Efanov AM, Gimeno RE, Scherer PE, Powers AC, Unger RH, Holland WL. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2022142118. doi: 10.1073/pnas.2022142118. 

​

PMID: 32428240

Dapagliflozin Does Not Directly Affect Human α or β Cells.

Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Endocrinology. 2020 Aug 1;161(8):bqaa080. doi: 10.1210/endocr/bqaa080.

​

PMID: 31941840

Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.

Dai C, Walker JT, Shostak A, Padgett A, Spears E, Wisniewski S, Poffenberger G, Aramandla R, Dean ED, Prasad N, Levy SE, Greiner DL, Shultz LD, Bottino R, Powers AC. JCI Insight. 2020 Jan 16;5(1):e130770. doi: 10.1172/jci.insight.130770.

 

PMID: 31653720

A Primary Role for α-Cells as Amino Acid Sensors.

Dean ED. Diabetes. 2020 Apr;69(4):542-549. doi: 10.2337/dbi19-0021. Epub 2019 Oct 25.

 

PMID: 31144717

Glucagon: The Name Says It All, or Not!

Dean ED, Vuguin PM, Charron MJ. Endocrinology. 2019 May 1;160(5):1359-1361. doi: 10.1210/en.2019-00251.

 

PMID: 30449685

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.

Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC. Cell Metab. 2019 Mar 5;29(3):745-754.e4. doi: 10.1016/j.cmet.2018.10.007.

 

PMID: 29106387

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion. Bozadjieva N; Blandino-Rosano M; Chase J; Dai XQ; Cummings K; Gimeno J; Dean D.; Powers AC; Gittes GK; Rüegg MA; Hall MN; MacDonald PE; Bernal-Mizrachi E. J Clin Invest. 2017 Nov 6. pii: 90004. doi: 10.1172/JCI90004.

 

PMID: 28591638

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC. Cell Metab. 2017 Jun 6;25(6):1362-1373.e5. doi: 10.1016/j.cmet.2017.05.011.

 

PMID: 28283660

Glucagon antagonism in islet cell proliferation.

Dean ED, Unger RH, Holland WL. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3006-3008. doi: 10.1073/pnas.1700468114.